Opisthorchiasis is an infection caused by either of the two parasite worms, the cat liver fluke, or scientifically called opisthorchis felineus also known as opisthorchis tenuicollis, or the southeast asian liver fluke called as opisthorchis viverrini. In this study we evaluate a pcrbased molecular identification method, multiplex ligationdependent probe. The present study developed an assay integrating realtime pcr and high resolution melting hrm analysis for the specific detection and rapid identification of c. Clonorchis sinensis infection has been reported from many parts of east asia russia, japan, korea and china, whereas o. The opisthorchis viverrini genome provides insights into life. The opisthorchis viverrini genome provides insights into. Aug 11, 2006 to clarify the genetic relationships between clonorchis sinensis and opisthorchis viverrini, patterns of interintraspecific polymorphism were compared for four markers with nuclear ribosomal dna rdna and mitochondrial dna mtdna in liver flukes c. These species of flukes are classified as group i carcinogens by the international agency for research on cancer iarc. Infections with the opisthorchid liver flukes clonorchis sinensis, opisthorchis viverrini, and o. Pdf opisthorchis viverrini and opisthorchis felineus. Media in category clonorchis sinensis the following 9 files are in this category, out of 9 total. Clonorchis sinensis infections are endemic in japan, korea, vietnam, and china. Additionally, cysts containing the parasite can sometimes be detected.
Rapid detection and differentiation of clonorchis sinensis. In addition to infecting humans, clonorchis can also infect dogs and cats. Oct 30, 2017 the liver fluke opisthorchis viverrini infects 10 million people in southeast asia and causes cholangiocarcinoma cca. Genetic comparison of liver flukes, clonorchis sinensis.
Clonorchis sinensis is endemic in southern china, korea and northern vietnam, whereas o. Nov 16, 2017 tribendimidine has a slightly lower cure rate than praziquantel and noninferiority was not shown. The tumorigenic liver fluke opisthorchis viverrini multiple. Clonorchis sinensis wikidoc schistosomatoza wikipedia, wolna encyklopedia. Pronunciation of clonorchis sinensis with 1 audio pronunciation, 1 meaning and more for clonorchis sinensis. Opisthorchiasis is a parasitic disease caused by species in the genus opisthorchis specifically, opisthorchis viverrini and opisthorchis felineus.
Our study included mainly adults and children with lowintensity o viverrini infection. Opisthorchis viverrini and clonorchis sinensis were considered by a previous iarc working group in 1994 iarc, 1994. Opisthorchis viverrini and clonorchis sinensis biological. Infections with the opisthorchid liver flukes clonorchis sinensis, opisthorchis. To clarify the genetic relationships between clonorchis sinensis and opisthorchis viverrini, patterns of interintraspecific polymorphism were compared for four markers with nuclear ribosomal dna rdna and mitochondrial dna mtdna in liver flukes c.
Both species are similar in morphology, life cycle, and mode of. Clonorchis sinensis, opisthorchis spp, and metorchis spp. Since that time, new data have become available, these have been incorporated in the monograph, and taken into consideration in the present evaluation. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Humans become infected by eating raw or poorly cooked fish containing the larval forms. Opisthorchis sinensis definition of opisthorchis sinensis. Opisthorchis tenuicollis definition of opisthorchis. The species known as clonorchis sinensis has sometimes been reclassified into the genus opisthorchis. Human small liver flukes are clonorchis sinensis, opisthorchis felineus, and opisthorchis viverrini. Efficacy and safety of tribendimidine against opisthorchis. Diemert, in infectious diseases fourth edition, 2017. Liver fluke infection with opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis remains a major public health problem in many parts of asia and eastern europe. After ingestion by a suitable snail first intermediate host, the eggs release miracidia, which undergo in the snail several developmental stages sporocysts, rediae. Jul 26, 2016 tribendimidine has excellent efficacy and tolerability at doses of 100 mg and above.
The distribution of the vitelline glands is also different. Opisthorchis felineus is a trematode that is transmitted to humans through the consumption of raw freshwater fish of the family cyprinidae. However, tribendimidine has a similar egg reduction rate to praziquantel and leads to fewer adverse events and thus might complement praziquantel in o viverrini control programmes, particularly in settings coendemic for hookworm. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that. From the greek opisthen behind and orchis testicle, opisthorchis is a genus of trematode flatworms whose testes are located in the posterior end of the body.
The tumorigenic liver fluke opisthorchis viverrinimultiple. Epidemiology and prevalence of clonorchis sinensis and opisthorchis viverrini infection in humans. Some of these parasites are highly associated with cholangiocarcinoma. The three epidemiologically important opisthorchiidae liver flukes opisthorchis felineus, o.
Clonorchis and opisthorchis clonorchis sinensis, opisthorchis viverrini, and o. We use your linkedin profile and activity data to personalize ads and to show you more relevant ads. The term fluke means flatfish, since these parasites are flat. Opisthorchis viverrini and clonorchis sinensis a opisthorchis viverrini thailand is the most endemic country for opisthorchiasis due to o. Distribution and abundance of opisthorchis viverrini. Author summary the oriental liver fluke, clonorchis sinensis, is a biological carcinogen of humans and is the cause of death of infectious cancer patients in china and korea. Clonorchis sinensis an overview sciencedirect topics. Infeetion with livr flukes opisthorchis viverrini, opisthorchis felineus and clonorchis sinensis 1. Clonorchis sinensis, opisthorchis viverrini and opisthorchis felineus are three closely related species that produce similar clinical manifestations in humans. The zoonotic, fishborne liver flukes clonorchis sinensis, opisthorchis felineus and. The adult flukes deposit fully developed eggs that are passed in the feces.
Trematode parasites of the genera clonorchis, opisthorchis and metorchis, commonly referred to as liver flukes, are transmitted to humans and other mammals by the ingestion of fish infected with their larval stages which. Early identification of the infection is essential to provide timely and appropriate chemotherapy to patients. Worldwide, the number of cases of human infection has been estimated to be 1. Chart and diagram slides for powerpoint beautifully designed chart and diagram s for powerpoint with visually stunning graphics and animation effects. Clonorchis sinensis and opisthorchis viverrini are both important fishborne pathogens, causing serious public health problem in asia. Trematode parasites of the genera clonorchis, opisthorchis and metorchis, commonly referred to as liver flukes, are transmitted to humans and other mammals by the ingestion of fish infected with their larval stages which ultimately come from snails infected due to excreta. Molecular identification of clonorchis sinensis and. Tribendimidine has a slightly lower cure rate than praziquantel and noninferiority was not shown. Opisthorchiasis and opisthorchisassociated cholangiocarcinoma in. Clonorchis sinensis, opisthorchis felineus and opisthorchis viverrini are the three most important liver flukes involved in human health, infecting more than 45 million people worldwide. Clonorchis sinensis wikipedia, a enciclopedia livre.
Infection with the parasite is called opisthorchiasis. Suppression of mrnas encoding cd63 family tetraspanins from. Opisthorchis felineus, a closely related species of trematode that infects various carnivores including humans, occurs throughout the philippines, india, japan, vietnam, and eastern europe, particularly poland and. Nov 17, 2014 clonorchis sinensis and opisthorchis species are important liver flukes of oriental or chinese origin 14. The eggs of opisthorchis are very similar to those of clonorchis, another liver fluke, but can be distinguished by microscopic features. Trematodes flukes opisthorchis viverrini southeast asian liver fluke and opisthorchis felineus cat liver fluke. Its common name, chinese liver fluke, comes from its abundance in these areas. Clonorchis sinensis is found mainly in eastern asia and south pacific asia. Clonorchis sinensis, the chinese liver fluke, is a liver fluke belonging to the class trematoda, phylum platyhelminthes. Our new crystalgraphics chart and diagram slides for powerpoint is a collection of over impressively designed datadriven chart and editable diagram s guaranteed to impress any audience. Clonorchiasis whose symptoms are indistinguishable from opisthorchiasis is one of the most neglected tropical diseases which blight the lives of millions of people worldwide and threaten the health of several others 5, 6. Opisthorchis viverrini life cycle pixelmasterdesign.
Clonorchis sinensis is distributed over multiple countries, including china, korea, vietnam, taiwan, japan, and others. Genetic comparison of liver flukes, clonorchis sinensis and. Opisthorchiasis is a major public health problem in southeast asia. After ingestion by a suitable snail first intermediate host, the eggs release miracidia, which undergo in the snail several developmental stages. Clonorchis sinensis informacion practica profesionales. Human illnesses caused by opisthorchis felineus flukes, italy. Its chronic infection promotes cholangiocarcinogenesis due to direct contact of host tissues with the worms and their excretorysecretory products esps.
Opisthorchis felineus has been documented in at least 12 countries of the european union, belarus, ukraine. Efficacy and safety of tribendimidine versus praziquantel. Clonorchis sinensis, opisthorchis viverrini, and o. The liver fluke opisthorchis felineus is a member of the triad of epidemiologically important liver fluke species belonging to the family opisthorchiidae and the major agent causing opisthorchiasis over a vast territory, covering russia, kazakhstan and several european countries. Download scientific diagram suppression of mrnas encoding cd63 family tetraspanins from the. It was discovered by a british physician james mcconnell at the medical college hospital in calcutta kolkata in 1874. The tumorigenic liver fluke opisthorchis viverrini. The usual methods of diagnosing these infections involve the demonstration of fluke eggs in stool samples under light microscopy, but sensitivity and specificity are low. Opisthorchis viverrini, common name southeast asian liver fluke, is a foodborne trematode parasite from the family opisthorchiidae that infects the bile duct. Trematode parasites of the genera clonorchis, opisthorchis and metorchis, commonly referred to as liver flukes, are transmitted to humans and other mammals by the ingestion of fish infected with their larval stages which ultimately come from snails. Affected individuals often have mixed infections with the liver fluke opisthorchis viverrini and minute intestinal flukes such as haplorchis taichui. Opisthorchis felineus is a member of the triad of epidemiologically important liver fluke species belonging to the family opisthorchiidae. Jul 18, 2018 the liver flukes, opisthorchis viverrini and clonorchis sinensis, are known to cause cholangiocarcinoma cca, a type of liver cancer that develops within the bile duct. Chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts.
In thailand and neighbouring countries, human opisthorchiasis is caused by o. Clonorchis sinensis and opisthorchis viverrini are clinically important small liver flukes because of their known association with development of cholangiocarcinoma. Humans or other mammals eat the encysted metacercariae in inadequately cookedrawpickled fish. In 198081, the prevalence in the north, northeastern, centre. Nevertheless, they are often underestimated compared to other, better known neglected diseases in spite of the fact that many millions of humans are infected and hundreds of millions at risk. Clonorchis sinensis excretorysecretory products increase. Opisthorchis viverrini an overview sciencedirect topics. Pcr diagnosis of opisthorchis viverrini and haplorchis. These species of flukes are classified as group i carcinogens by the. Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. In humans, it infects the common bile duct and gall bladder, feeding on bile.